The First Ig Domain of KIR3DL1 Contacts MHC Class I at a Secondary Site

MHC Class I at a Secondary Site The First Ig Domain of KIR3DL1 Contacts

Leukocyte Ig-Like Receptors – A Model for MHC Class I Disease Associations

MHC class I (MHC-I) polymorphisms are associated with the outcome of some viral infections and autoimmune diseases. MHC-I proteins present antigenic peptides and are recognized by receptors on natural killer cells and cytotoxic T lymphocytes, thus enabling the immune system to detect self-antigens and eliminate targets lacking self or expressing foreign antigens. Recognition of MHC-I, however, ...

MHC class I multimers

T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach t...

MHC Molecule Outside the Peptide-Binding Site of a Class I A Region of Conformational Variability

HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T cells classically associated with the detection of missing self through loss of their respective MHC ligand. Some KIR specificities for allelic classical class I MHC (MHC-I) have been described, whereas other KIR receptor-ligand relationships, including those associated with nonclassical MHC-I, have yet to be clea...